The Essential Kit for Studying Drug Interactions with Cellular Transporters
Researcher looking for a reliable BCRP kit and a reputable company? Our PreadyPort kit provides scientists with fair prices, on-demand delivery, and consistent results for analysis of drug interactions with efflux transporters.
Our kit is a breakthrough. It is a ready-to-use solution for MDCKII-BCRP monolayer assays. Licensing and cell culturing are no longer an issue because our kit provides a full-service approach to performing BCRP interaction studies on monolayers.
Our package offers cost-effective solutions without the need for in-house cell production management.
Experience the efficiency, reliability, and adaptability of PreadyPort BCRP. Propel your research forward with confidence and uncover new insights in the vein of drug transportation.
It includes 24 and 96 well-insert-integrated plates with specialized MDCKII cells expressing BCRP, as well as the parental cell line.
|PreadyPort BCRP Kit FORMATs||Product Numbers|
|PreadyPort-BCRP/CTRL 1:1 (24-Multiwell)||KRECE-BCP02|
|PreadyPort-BCRP/CTRL 1:1 (96-Multiwell)||KRECE-BCP51|
|PreadyPort-BCRP/CTRL Custom setup (96-Multiwell)||KRECE-BCP60|
It is an advanced solution for studying how drugs interact with cellular transporters in a controlled laboratory environment. It includes specialized plates with MDCKII cells expressing BCRP, allowing researchers to explore drug interactions with efflux and uptake transporters.
BCRP Substrates include chemotherapeutic agents including tyrosine kinase inhibitors gefitinib and imatinib, mitoxantrone, irinotecan, and its active analog SN-38. Non-chemotherapeutic drugs included are glyburide, dipyridamole, and prazosin. Compounds that are not therapeutic are porphyrins, dietary flavonoids, carcinogen PhIP, and estrone 3-sulfate(E1S) (Ni et al., 2010) (Tamaki et al., 2010).
The inhibitors of BCRP include, but are not limited to, the FTC analogue Ko143, fumitremorgin C (FTC), anti-HIV protease inhibitors ritonavir and nelfinavir, the acridone carboxamide derivative GF120918, and herb extracts (Ni et al., 2010).
The PreadyPort BCRP Kit offers advantages such as:
The PreadyPort BCRP Kit’s versatile uses include:
Yes, the effectiveness of the PreadyPort BCRP Kit is supported by scientific literature. Three notable papers highlight the suitability of Caco-2 cells, which are used in the kit, for testing drug permeability in various drug development studies.
For detailed insights and growth forecasts in the cell permeability testing market, please visit our dedicated Market-Forecasts page. Stay informed about market trends and gain a competitive edge in this thriving industry.