The Adaricell BCRP Kit:
The Essential Kit for Studying Drug Interactions with Cellular Transporters
Researcher looking for a reliable BCRP kit and a reputable company? Our PreadyPort kit provides scientists with fair prices, on-demand delivery, and consistent results for analysis of drug interactions with efflux transporters.
Streamlining BCRP Interaction Studies:
Our kit is a breakthrough. It is a ready-to-use solution for MDCKII-BCRP monolayer assays. Licensing and cell culturing are no longer an issue because our kit provides a full-service approach to performing BCRP interaction studies on monolayers.
Various PreadyPort BCRP Applications:
- BCRP Substrate Assessment: Perform optimal direct transport research with our kit, allowing you to assess the substrates of BCRP and gain insights into their transportation mechanisms (Giri et al., 2009).
- Inhibitor Assessment: Evaluate the effectiveness of BCRP inhibitors and understand one of the efflux transporters responsible for drug resistance (Mao & Unadkat, 2014).
- Modeling Net Transporter Events: Gain a comprehensive understanding of cellular transport phenomena by simulating net transporter events. It mimics the behavior of excretory cells and physiological barriers like the human blood-brain barrier, gastrointestinal tract, and placenta (“Membrane Transporters in Drug Development,” 2010).
Regulatory Compliance: PreadyPort BCRP Meets FDA Requirements
- Our BCRP kit aligns with the stringent standards set by the U.S. Food and Drug Administration (FDA) for the final preclinical analysis of drugs.
- This product is manufactured in strict accordance with ISO 9001:2015. This internationally recognized quality management standard guarantees our commitment to reliability and compliance.
PreadyPort BCRP: Backed by Scientific Research
- Explore the credible literature supporting the effectiveness of PreadyPort BCRP. Our product has been featured in three notable papers, highlighting the suitability of Caco-2 cells for testing permeability in various drug development studies.
- BCRP has specifically demonstrated efficacy in evaluating transporter involvement (Mukkavilli et al., n.d.).
- You can find out more about BCRP and some peer-reviewed studies on the subject on our website.
Advantages of our Assay Kit
Our package offers cost-effective solutions without the need for in-house cell production management.
- With our proprietary shipping medium, the kits will remain stable during transportation and can be stored at room temperature, eliminating the hassle of complex storage requirements.
- PreadyPort BCRP kits are shipped on the fifth day of cell differentiation. After a brief incubation period, typically between days twelve and fifteen, the kit is ready for compound analysis, Our extensive testing consistently demonstrates outcomes that meet and exceed expectations.
- The PreadyPort BCRP kit is easily customizable and compatible with automation systems, allowing for seamless integration into high-throughput screening processes.
Experience the efficiency, reliability, and adaptability of PreadyPort BCRP. Propel your research forward with confidence and uncover new insights in the vein of drug transportation.
Physical Item
It includes 24 and 96 well-insert-integrated plates with specialized MDCKII cells expressing BCRP, as well as the parental cell line.
In Addition to the BCRP plates, the following Items are included:
- SMDCK-M500 Supplement – 500 mL Standard MDCK II Cell Culture Medium
- S-HBSS500 Supplement – 500 mL HBSS Transport Buffer (1X) + Ca2+ /Mg2+
- S-MDCK-SB150 Supplement – 150mL Induction of BCRP Expression Solution
Explore the Cell Permeability Testing Market
- Our forecasts provide valuable insights into the current and future landscape of this thriving industry. Visit our dedicated Market-Forecasts page. Gain a competitive edge and make informed decisions in the cell permeability testing market.
Conclusion
- At Adaricell, we give researchers tools that make their lives easier. We assess problems like having to do in-house cell production and solve them by doing it for you in an easy and accessible way. Request a manual and we’ll give you all the details you need! Manual request.
PreadyPort BCRP Chart
| PreadyPort BCRP Kit FORMATs | Product Numbers |
|---|---|
| PreadyPort-BCRP (24-Multiwell) | KRECE-BCP01 |
| PreadyPort-BCRP/CTRL 1:1 (24-Multiwell) | KRECE-BCP02 |
| PreadyPort-BCRP (96-Multiwell) | KRECE-BCP50 |
| PreadyPort-BCRP/CTRL 1:1 (96-Multiwell) | KRECE-BCP51 |
| PreadyPort-BCRP/CTRL Custom setup (96-Multiwell) | KRECE-BCP60 |
| PreadyPort-CTRL (24-Multiwell) | KRECE-CTR01 |
| PreadyPort-CTRL (96-Multiwell) | KRECE-CTR50 |
FAQ (Frequently Asked Questions)
What is the Adaricell BCRP Kit and what is its purpose?
It is an advanced solution for studying how drugs interact with cellular transporters in a controlled laboratory environment. It includes specialized plates with MDCKII cells expressing BCRP, allowing researchers to explore drug interactions with efflux and uptake transporters.
What Drugs are BCRP Substrates
BCRP Substrates include chemotherapeutic agents including tyrosine kinase inhibitors gefitinib and imatinib, mitoxantrone, irinotecan, and its active analog SN-38. Non-chemotherapeutic drugs included are glyburide, dipyridamole, and prazosin. Compounds that are not therapeutic are porphyrins, dietary flavonoids, carcinogen PhIP, and estrone 3-sulfate(E1S) (Ni et al., 2010) (Tamaki et al., 2010).
What are BCRP Inhibitors
The inhibitors of BCRP include, but are not limited to, the FTC analogue Ko143, fumitremorgin C (FTC), anti-HIV protease inhibitors ritonavir and nelfinavir, the acridone carboxamide derivative GF120918, and herb extracts (Ni et al., 2010).
What are the benefits of using the PreadyPort BCRP Kit?
The PreadyPort BCRP Kit offers advantages such as:
- Convenience: Our kit provides a streamlined approach to studying drug interactions on monolayers by doing the licensing and cell culturing for users.
- On-demand delivery: Delivering kits when you need them.
- Reliable and reproducible results: The kit has demonstrated high reproducibility, ensuring consistent outcomes.
- Easy integration and automation: The PreadyPort BCRP Kit is easily adaptable to automation systems, making it compatible with high-throughput screening processes.
- Regulatory compliance: The kit meets FDA requirements for the final preclinical analysis of drugs and is manufactured in accordance with ISO 9001:2015.
What are the various applications of the PreadyPort BCRP Kit?
The PreadyPort BCRP Kit’s versatile uses include:
- Substrate assessment: Evaluate the transportation mechanisms of BCRP substrates for direct transport studies.
- Inhibitor assessment: Assess the effectiveness of BCRP inhibitors and their impact on transport processes.
- Modeling net transporter events: Simulate net transporter events in excretory cells and physiological barriers like the human blood-brain barrier, gastrointestinal tract, and placenta.
Is the PreadyPort BCRP Kit supported by scientific research?
Yes, the effectiveness of the PreadyPort BCRP Kit is supported by scientific literature. Three notable papers highlight the suitability of Caco-2 cells, which are used in the kit, for testing drug permeability in various drug development studies.
How can I access more information about the cell permeability testing market?
For detailed insights and growth forecasts in the cell permeability testing market, please visit our dedicated Market-Forecasts page. Stay informed about market trends and gain a competitive edge in this thriving industry.