CacoGoblet
A mucus secreting ready-to-use concept for intestinal absorption evaluation.
Adari Cell Science offers ready to use CacoGoblet kits.
A mucus-secreting ready-to-use cell-based assay for rapid assessment of drugs ability to cross the intestinal epithelium. The kit consists of 24- or 96-well permeable supports seeded with differentiated polarized Caco-2 and human goblet cells on polycarbonate micropore filters.
CacoGoblet Applications
- Evaluation of oral absorption efficiency, oral bioavailability and oral toxicity
- Adaptation to high throughput screening of target compounds
- Study of mechanisms involved in oral and intestinal absorption
- Suitable for research on new delivery systems
CacoGoblet FDA requirements
These four evaluation results pertaining to the compounds evaluated from data generated by the CacoGoblet kits are required by the FDA:
- Permeability Assay
- P-gp interactions
- BCRP interactions
- Toxicology Studies
CacoGoblet is a product manufactured in compliance with ISO 9001:2015
CacoGoblet Benefits
- CacoGoblet assays are cost effective and don’t not require the management of site/in house cell propagation
- Testing kits are available on demand according to testing schedule
- Shipped on day five of cell differentiation
- Proprietary shipping medium allows for kits to be shipped and stored at room temperature
- After incubation, kits are ready to assay with your compounds on days twelve through fifteen
- More predictive model for compounds or formulations with passive diffusion transport pathway
- The CacoGoblet kit has demonstrated high reproducibility
- Easily adaptable to throughput automation
- Extensive testing experience demonstrates that results meet or surpass expectations.
- Discounted evaluations are available today
Download CacoGoblet Technical Sheet
CacoGoblet Chart
| CacoGoblet Kit FORMATs | Product Numbers |
|---|---|
| CacoGoblet 24 Transwell | KRECE-CCG01 |
| CacoGoblet 24 (individual transwell) | KRECE-CCG02 |